| Name | : | Dr. JYOTIRMOY GHOSH |
| Designation | : | Scientist |
| Qualification | : | Ph.D.(Bose Institute, Jadavpur University) Post Doctoral Research Fellow (University of Pennsylvania, USA) |
| Contact Details | : | Natural Product Chemistry Division, CSIR-NEIST, Jorhat-785006, Assam, India. |
| Email id | : | bichemjyoti@gmail.com |
Research Interest
- Investigation of cell signaling mechanism in toxin and drug induced organ pathophysiology.
- Free Radical Chemistry and Biology.
- To find out novel strategies to mitigate the potential side effect of drug using antioxidant
- Studies on the signal transduction mechanism of cell death and survival.
- Determination of bio efficacy of organic molecules and extracts.
- Isolation and purification of the bio-active principle(s) from herbal plants and unravelling the mechanisms and exploring the antitoxic/antioxidant potentials of these phytochemicals (natural and man-made antioxidants).
List of Publications (Most Recent Ten)
Total No. of Publications: 23 (SCI Journals)
and Book Chapter 3
- Ghosh J and Sil PC. Arjunolic acid: A new multifunctional therapeutic promise of alternative medicine. Biochimie. 2013; 95: 1098-1109. (Impact Factor 2012: 3.1; 5- year Impact Factor: 3.555)
- Ghosh J, Das J, Manna P, Sil PC. The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53 mediated cardiac apoptosis. Biomaterials. 2011; 32: 4857-4866. (Impact Factor 2012: 7.604; 5- year Impact Factor: 8.496)
- Ghosh J, Das J, Manna P, Sil PC. Hepatotoxicity of di-(2-ethylhexyl)-phthalate (DEHP) is attributed to calcium aggravation, ROS-mediated mitochondrial depolarization and ERK/NF-B pathway activation. Free Radical Biology and Medicine. 2010; 49: 1779-1791. (Impact Factor 2012: 5.271; 5- year Impact Factor: 5.969)
- Ghosh J, Das J, Manna P, Sil PC. Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection. Free Radical Biology and Medicine. 2010; 48: 535-553. (Impact Factor 2012: 5.271; 5- year Impact Factor: 5.969)
- Ghosh J, Das J, Manna P, Sil PC. Acetaminophen induced renal injury via oxidative stress and TNF-a production: Therapeutic potential of arjunolic acid. Toxicology. 2010; 268: 8-18. (Impact Factor 2012: 4.017; 5- year Impact Factor: 3.763)
- Ghosh J, Das J, Manna P, Sil PC. Protective effect of the fruits of Terminalia arjuna against cadmium-induced oxidant stress and hepatic cell injury via MAPK activation and mitochondria dependent pathway. Food Chemistry. 2010; 123: 1062-1075. (Impact Factor 2012: 3.334; 5- year Impact Factor: 4.072)
- Ghosh J, Das J, Manna P, Sil PC. Taurine prevents arsenic-induced cardiac oxidative stress and apoptotic damage: Role of NF-kB, p38 and JNK MAPK pathway. Toxicology and Applied Pharmacology. 2009; 240: 73-87. (Cover page article) (Impact Factor 2012: 3.975; 5- year Impact Factor: 4.116)
- Das J, Ghosh J, Manna P, Sil PC. Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK. Biochemical Pharmacology. 2011; 81(7): 891-909. (Impact Factor 2012: 4.576; 5- year Impact Factor: 4.529)
- Manna P, Das J, Ghosh J, Sil PC. Contribution of type 1 diabetes to rat liver dysfunction and cellular damage via activation of NOS, PARP, IκBα/NF-κB, MAPKs and mitochondria dependent pathways: Prophylactic role of arjunolic acid. Free Radical Biology and Medicine. 2010; 48(11):1465-1484. (Impact Factor 2012: 5.271; 5- year Impact Factor: 5.969)
Awards and Fellowships
- Postdoctoral research Fellowship from the University of Pennsylvania, USA.
- Prof. B. K. Bhattacharya memorial award for Securing highest marks in organic chemistry papers (Theoretical and Practical) at the Master of Science Part I and Final Examinations in Chemistry.
