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सीएसआईआर - उत्तर पूर्व विज्ञान एवं प्रौद्योगिकी संस्थान
CSIR-North East Institute of Science and Technology

A Constituent laboratory of Council of Scientific and Industrial Research (CSIR)

Ministry of Science and Technology, Govt. of India
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सीएसआईआर - उत्तर पूर्व विज्ञान एवं प्रौद्योगिकी संस्थान
CSIR-North East Institute of Science and Technology

Bio-Data

Bio-Data

Particulars of organization, functions and duties

Dr Srinivas Ambala

Dr Srinivas Ambala

Designation : Scientist C

Education : Ph.D

ID. No.: 1343

Email id : ambalasrinivas2512@gmail.com, srinivas@neist.res.in

Research Interest

1. Drug discovery and medicinal chemistry

2. Design and synthesis of small molecules for cancer, infectious diseases, and CNS disorders

3. Development of synthetic methodologies for C–C, C–N, C–O, and C–S bond formations

4. Semi-synthetic modification and diversity-oriented synthesis of natural products

5. Structure–activity relationship (SAR)-driven optimization of lead molecules

Projects

  • Title: Exploiting Bergenin and Its Derivatives for Natural Product-Based Drug Discovery in Rheumatoid Arthritis Unlocking Anti-Inflammatory and Antinociceptive Potential Targeting IL-6 Role: Principal Investigator (PI).

List of Publications

  • Ambala, S.; Singh, R.; Singh, M.; Cham, P. S.; Munagala, G.; Yempalla, K. R.; Vishwakarma, R. A.; Singh, P. P. Metal-free, room temperature, acid–K₂S₂O₈ mediated method for the nitration of olefins: an easy approach for the synthesis of nitroolefins. RSC Adv., 2019, 9, 30428–30431. https://doi.org/10.1039/C9RA05460G
  • Raga Chaitanya Kalakonda, Srinivas Ambala, Jagadeesh Babu Nanubolu, and Bathini Nagendra Babu. Copper-Mediated ortho-Selective C(sp2)−H Functionalization of Carboxylic Acid Derivatives with N(sp2)−H Sulfonimidamides: A Mild and General Strategy for C−N Bond Formation Org. Lett. 2025, 27, 9587−9592 https://doi.org/10.1021/acs.orglett.5c02464
  • Kalakonda Raga Chaitanya, Srinivas Ambala, Bheeshma Geetanjali Kodiripaka and Bathini Nagendra Babu. Regioselective alkenylation of masked carboxylic acid derivatives of coumarins with acrylates via oxidative C(sp2)–C(sp2) cross coupling. New J. Chem., 2024, 48, 19742-19745 DOI: 10.1039/D4NJ04014G
  • Gopathi, R.; Ambala, S.; Bathini, N. Regioselective ring expansion of 3 ylideneoxindoles with tosyldiazomethane (TsDAM): A metal-free and greener approach for the synthesis of pyrazolo-[1,5 c]quinazolines. J. Org. Chem., 2020, 85 (8), 5370–5378. https://doi.org/10.1021/acs.joc.0c00267
  • Ambala, S.; Thatikonda, T.; Sharma, S.; Munagala, G.; Yempalla, K. R.; Vishwakarma, R. A.; Singh, P. P. Cross-dehydrogenative coupling of α-C(sp³) H of ethers/alkanes with C(sp²)–H of heteroarenes under metal-free conditions. Org. Biomol. Chem., 2015, 13, 11341–11350. https://doi.org/10.1039/C5OB01752D
  • Ambala, S.; Kimberleigh, B.; Kamal, K.; Thavendran, G.; Hendrik, G.; Naicker, T.; Arvidsson, P. I. N-Arylation of primary and tertiary sulfonimidamides (SIAs) with benzyne precursors under transition metal-free conditions. Tetrahedron Lett., 2023, 124, 154583. https://doi.org/10.1016/j.tetlet.2023.154583
  • Singh, P. P.; Gudup, S.; Ambala, S.; Singh, U.; Dadwal, S.; Sawant, S. D.; Vishwakarma, R. A. Iron oxide mediated direct C–H arylation/alkylation at α-position of cyclic aliphatic ethers. Chem. Commun., 2011, 47, 5852–5854. https://doi.org/10.1039/C1CC11464D

List of Key Patents with brief description

  • Title: Inhibitors to Target HIV 1 NEF–CD80/CD86 Interactions for Therapeutic Intervention Inventors: Mayor, S.; Vishwakarma, R. A.; Singh, P. P.; Swetha, S.; Ambala, S.; Munagala, G.; Yempalla, K. R. et al. Description: This invention discloses small-molecule inhibitors that block the interaction between HIV-1 Nef protein and host immune receptors CD80/CD86, offering a novel therapeutic approach for HIV/AIDS. Status: Filed Patent Application No.: WO2020035880A1 Year: 2020
  • Title: Inhibitors to Target HIV 1 NEF–CD80/CD86 Interactions for Therapeutic Intervention Inventors: Mayor, S.; Vishwakarma, R. A.; Singh, P. P.; Swetha, S.; Ambala, S.; Munagala, G.; Yempalla, K. R. et al. Description: Japanese national phase of the above PCT application, granted for the same invention in Japan. Status: Granted Patent No.: JP2021535200A Year: 2021

CSIR-North East Institute of Science & Technology

सीएसआईआर - उत्तर पूर्व विज्ञान एवं प्रौद्योगिकी संस्थान

North East Institute of Science and Technology, Jorhat, Assam, a constituent establishment of Council of Scientific and Industrial Research (CSIR), New Delhi, has been engaged in multidisciplinary R&D work relevant to the country in general and North Eastern Region in particular.

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