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सीएसआईआर - उत्तर पूर्व विज्ञान एवं प्रौद्योगिकी संस्थान
CSIR-North East Institute of Science and Technology

Highlight

Applied Organic Chemistry Group

Highlight of the Group:
Applied Organic Chemistry Group (AOCG), which is under Chemical Science & Technology Division (CSTD) of CSIR-NEIST, Jorhat is dedicated for frontline research in applied & application oriented basic organic chemistry. The group is actively engaged, for last several years in the area of bioactive molecules with main emphasis being laid on the development of process route for drugs/drug intermediates and synthesis of new molecular entities (NMEs) on lead molecules as well as for lead generation. The main focus on the synthesis of new molecular entities is based on known drug molecules and bioactive molecules identified from natural sources. A major thrust of the AOCG is directed in the development of process/heterogeneous recyclable catalyst for industrially important speciality chemicals. The group is also involved in the synthesis of stable metal nanoparticles on nanoporous biopolymers/cellulose templates and their application in organic synthesis.

Project Leader

Mr Dipankar Neog

Sr. Principal Scientist

Education : BE (Mechanical Engg), M Tech (Petroleum Exploration & Production)

Employee ID: 1054

Email: dneog@neist.res.in

Contact details : +91 0376-2370117 | Fax: 0376-2370011

Areas of interest : Engineering design, Mathematical modelling

Activity Incharge

Mr Dipankar Neog

Sr. Principal Scientist

Education : BE (Mechanical Engg), M Tech (Petroleum Exploration & Production)

Employee ID: 1054

Email: dneog@neist.res.in

Contact details : +91 0376-2370117 | Fax: 0376-2370011

Areas of interest : Engineering design, Mathematical modelling

R&D Programs

Applied Organic Chemistry Group

R&D PROGRAMMES:

Speciality Chemicals:

  • Development of eco-friendly processes for the preparation of value added chemicals from wastes like rice straw, bamboo, grass etc
  • Oxidative transformation of lignin/degraded lignin products generated from microbially treated lignocellulosic materials’ for value addition

Small molecule libraries as anticancer and anti tuberculosis agent:

  • Synthesis of prenylated coumestane natural products like psoralidin, lespeflorin, glycyrol etc. and study of their activity against prostate cancer
  • Synthesis of small molecule libraries of Natural Products (NPs) and Natural Product like Molecules (NPLMs) by Function Oriented Synthesis (FOS), Diversity Oriented Synthesis (DOS), Diverted Total Synthesis (DTS), Target Oriented Synthesis (TOS) etc. for cancer therapy.
  • Synthesis of substituted quinoxaline and quinazoline derivatives for new anti tuberculosis agent

Development of methodology for the synthesis of promising organic molecules:

  • Development of methodologies involving C-C bond and C-X bond formation reactions
  • Development of methodologies for new scaffold library synthesis involving cascade/domino reactions
  • Application of green chemistry principals in synthesis of novel scaffolds

Development of synthetic methodologies for azaspirocyclic natural products like histirionicotoxin, erythratidinone, erysotramidine etc.

Acheivements

The AOCG has brought laurels to the institute by receiving several recognition and award at the National/International/State level which includes Fellow of the Indian National Science Academy (INSA), National Academy of Sciences (FNASc), CRSI Bronze Medal, Professor Harish Chandra Goswami Memorial Fellowship, Alexander von Humboldt fellowship (AvH), Germany, Dr Biraj Mohan Das Memorial Science Award, Elsevier Most Cited Paper Award etc

Research Facilities

The laboratory is well equipped with instruments like Polarimeter, Microwave reactor, Microwave Synthesis System, Flash chromatography, HPLC, Kugelrohr apparatus, Pressure reactor, Nitrogen gas generator, Low temperature bath (- 30 °C, -80 oC), Combiflash, Hydrogenation apparatus, Refrigerated centrifuge, Sonicator et